Dren was created by Elsa and Clive, two scientists who mixed human with multiple animal DNA. Starring the French actress Delphine Chaneac, the movie Splice from 2009 is a weird sci-fi horror movie and wonderful tale of science gone mad has two scientists pushing the boundaries of genetic splicing and DNA work to create a visually stunning monster.

While Dren starts as a freak of genetics and a bundle of animal and human hybrid cells, she slowly evolves and becomes a buck-legged creature who falls for her creator Clive Nicoli (Adrien Brody) and becomes jealous of his gal Elsa Kast (Sarah Polley).

The Dren creature is a superb mix of acting, CG work, and special effect make-up, especially when the wings and teeth start to show.

Splice was directed by Vincenzo Natali and starred Adrien Brody, Sarah Polley, and Delphine Chanéac. With Guillermo del Toro, Don Murphy, and Joel Silver as executive producers.